Notions of justice in relation to climate change invoke multiple expressions of responsibility. In this context, cities become important sites for interrogating the social, scalar and spatial processes that underpin climate (in)justice and analysing how moral and political responsibilities are shaped. To date, cities have been framed as both causally responsible for carbon emissions while also vulnerable to climate impacts such as flooding or heatwaves. Such frameworks nonetheless remain limited, not only in terms of their capacity to fully capture the politics and contestation of urban climate responsibility but also in accounting for spatial difference in how climate responsibility is mobilised and practiced across cities. This paper considers the interconnections between responsibility and urban climate justice in the context of the Asia Pacific region. It draws on a systematic literature review and an assessment of climate policies in cities across the Asia Pacific. The paper reflects on the multiple meanings of responsibility in the face of regionally-specific urban climate transformations and diverse modes of climate activism. In so doing, it offers new theoretical perspectives on the shifting relationship between cities, climate justice and responsibility.